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Acute exposure of Caco-2 cells to alcohol was associated with perturbations of Rap2 and MLCK activity, signalling molecules regulated downstream of JAM-A, demonstrating the critical role of JAM-A in the regulation of paracellular permeability ( in vivo through regulation of a promigratory protein signalling complex between Rap1A, Talin, and 1 integrin (Fan et al., 2022)

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